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    Everything Options

    Read this thread a bit and did my first options trade over the last week. Purchased some Vaxart $VXRT puts because they were experiencing a run-up on some hype for their vaccine. I have been following their data for the last year and I've been unimpressed by their results so I was very doubtful...
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    The Loss-Pron Thread

    Not a loss that I could do much about, but in the last year my company stock options (and some RSUs) have fluctuated in value from nearly nothing, to $1M (about 50% vested at the time), all the way back to about $50k. Unfortunately we were in a trading blackout for most of the year during all...
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    Desktop Computers

    As an update, I kept both PCs and gave my wife the 3060 Ti build. Added some thermal paste inside the 3080 and it helped a lot with the vram temps hitting >100 and everything is going really smoothly. May replace the front case fan but honestly it's pretty quiet unless it ramps to 100% which...
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    Health Problems

    As an update, I'm glad everyone I've talked to has emphasized to take it slowly. Almost 4 weeks post op and I'm still not able to walk without a limp and the hip feels really "tight" when I use it. Only sharp pain I get is muscle spasms after exercises or during stretching if the range of motion...
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    Mortgage refinance offers

    We refinanced from 4.125 to 3.75 last year and are saving about $700/mo (new appraisal was quite a bit higher then it was when we bought it in 2018 so PMI dropped a lot), and also got about $9k back in cash since we accepted a higher rate (we are planning on moving in a year or two). Literally...
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    Health Problems

    Thanks for the insight. I had similar surgery (femoroplasty + labral repair + capsule closure, no microfracture) but only on my painful symptomatic hip. I'll eventually need it on the other side MRI showed a torn labrum there as well but so far it doesn't ache after activity the way the left one...
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    Going to College as an Adult

    MBA is a degree that's perfectly designed for an experienced professional. I always crack up when I read job applications from 22 year old applicants for management positions because they got an MBA right after their bachelor's without ever holding a real job. They are usually super ambitious...
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    Health Problems

    Just had surgery to repair hip impingement + torn labrum. Not sure if anyone's been through that, but so far it seems similar to other sports leg injuries: ice, crutches, CPM machine, etc. Still on Day 1 so we'll see if I end up needing the painkillers or not. Really odd how there is some sharp...
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    NVidia GeForce RTX 30x0 cards

    I might, honestly. 3060 ti build already shipped so it's either return or resell.
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    NVidia GeForce RTX 30x0 cards

    My desktop is still on an i5-3570k and the only upgrade I've made in 8 years is an RX 570 so I'm glad I asked!
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    Desktop Computers

    I probably should have posted this here instead of in the 30X0 thread: Need some feedback on two orders I placed. I'm trying to decide which to keep. The first build is arriving this weekend and the second one will ship sometime in April. I currently have 2x 60Hz 1080p monitors but will...
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    NVidia GeForce RTX 30x0 cards

    Need some feedback on two orders I placed. I'm trying to decide which to keep. The first build is arriving this weekend and the second one will ship sometime in April. I currently have 2x 60Hz 1080p monitors but will probably upgrade to 1440, maybe 120/144Hz. Don't currently care about 4k...
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    Cyberpunk 2077

    Try minimizing big picture mode and starting the game from the desktop.
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    Investing General Discussion

    I had been holding VIR for about 9 months and just sold yesterday... Woops.
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    Investing General Discussion

    Well, that was an easy call for a 25% gain. MRNA was $77 when I posted this and it's around $100 today after they posted their efficacy. Might bump a little more or more likely will settle lower by the end of the week. All their preclinical data was really similar to Pfizer and they use using a...
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    Investing General Discussion

    It blows my mind that the opinion of someone like Andrew Left holds any weight, let alone enough to crash stocks the way he does over and over. Some of Citron's "research" papers are hilarious at how inaccurate and poorly-written they are, yet somehow they create a self-fulfilling prophecy that...
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    The Haunting of Bly Manor

    I enjoyed it, but I would have enjoyed it more if we didn't have the first season as a reference point for what the series is capable of. As a lot of you have mentioned, the plot here is much more of a slow burn, and there are no real dramatic twists. I remember how shocking it was to find out...
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    Investing General Discussion

    Moderna will likely be reporting efficacy data soon for its COVID vaccine. If you feel like gambling, this could really swing things up or down in the coming days (weeks?) depending on their efficacy numbers. All their data so far has looked great, but with such an early readout from a small...
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    Investing General Discussion

    To be fair, that's just placing an order to call dibs once doses are available. I guess it's nice that the money came from OWS, but some US agency would have ended up paying to reserve doses regardless. I'm not aware of Pfizer receiving any actual OWS support, and they are even using their own...
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    Investing General Discussion

    For anyone wondering if the Pfizer news is really that great: yes, in terms of vaccine effectiveness. 90% efficacy is great. If none of the vaccinated patients advance to severe disease then that's even better news, obviously. There's no bad news in this press release, but the safety profile...
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    Parent Thread

    I think it's just random. Our second kid cried all the time and our first hardly ever cried.
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    Investing General Discussion

    I am shocked that it looks like it will get approval - I guess the desperation for any treatment option justified a bit of a fishing expedition for any efficacy signal. For many years, A-beta antibodies have been used with varying degrees of success to reduce some symptoms, but the amyloid...
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    Dark

    Decided to check this show out and powered through over the last couple weeks. I managed to avoid spoilers and I think for this show in particular it made things a lot more enjoyable. Towards the end - I guess for most of the third season - I did end up reading the wiki summary after finishing...
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    Health Problems

    When I was interviewing for a job at Mayo in Rochester, I was told that it is quite common for middle eastern royalty to fly their family and friends straight in and pay in cash, even for minor ailments. Apparently there are also exceptionally high rates of rare inherited disorders because there...
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    Going to College as an Adult

    Impressed by those of you willing to dive back in to the pool of homework and exams. Finally being finished with coursework for good was one of the best / most liberating feelings in my life. I really enjoyed grad school in particular due to the focused nature of many courses, but I never...
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    Investing General Discussion

    Keep in mind that study completion dates can be very misleading. A typical Phase 3 vaccine study will takes years. But then again, a typical Phase 1 study also takes a year or two, and we are seeing multiple companies skipping straight from Phase 1 to Phase 3 within months now. All the Phase 1...
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    Investing General Discussion

    Moderna is close to $100 per share now. $35B market cap and they haven't yet dosed a patient for phase 3. Very tempted to sell before the pullback, but I got burned doing that with NVAX so I'm just going to be patient and wait for approvals. If you are doing short term trading, all the vaccine...
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    Investing General Discussion

    Haha, well I can only assume the "double defense" refers to the hype/rumor that the Oxford + Astrazeneca vaccine is generating antibody and killer T cell responses, which would be very encouraging. As for the decades of protection... Uhh, maybe? I guess we'll find out in a couple decades? I...
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    Investing General Discussion

    Happy to help. 99% of this thread goes over my head, but I live and breathe the scientific side of biotech / pharma so hopefully it adds an interesting perspective.
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    Investing General Discussion

    Let me clear up some misinformation before this spreads anymore: Moderna, and all other frontrunners have completed animal challenge studies. A pre-print of their results in mice has been available for over a month, and I can guarantee you that they have completed NHP (monkey) challenge(s) as...
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    Investing General Discussion

    Definitely safer to stick with big pharma, and much bigger risk/reward with the small players. I invest for fun so I am most interested in trying to pick a winner based on "up-and-coming" technology. But I'm also prepared to see it all disappear with no warning.
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    Investing General Discussion

    BNTX up 18% so far. Although, all the big COVID vaccine stocks are all up 10% or so right now. It's almost a guarantee that there will be some more funding announcements soon for some of the frontrunners in the vaccine race. There's a whole lot of Warp Speed, DoD, CEPI, Gates, GAVI, etc...
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    Parent Thread

    You're in California right? Take the 6 weeks of paid family leave to bond. For my kids, I took the 6 weeks starting when they were about 3 months old. I got to be there for their first laughs, their attempts to crawl and roll over, and I spent a lot of time learning their habits and figuring out...
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    Investing General Discussion

    If you are following vaccine stocks, I would own BioNTech (BNTX) since they developed the vaccines and licensed to Pfizer. Obviously Pfizer can benefit from all this but I think BNTX is the one that can really explode. I'd also expect MRNA to report their complete phase 1 data soon (possibly...
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    Investing General Discussion

    This drop is hitting every company though. Probably the biggest drop in this industry since the pandemic hit. I think a lot of portfolios are unloading to take profits in case the pandemic dies down before Ph1 readouts start to trickle in and Ph2-3 studies kick off. I still think buying the...
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    Investing General Discussion

    Covid stocks getting annihilated across the board today.
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    Investing General Discussion

    They have a lot riding on their Alzheimer's drug, so their value this year might be tied to whether or not the BLA gets accepted by the FDA this fall/winter. If approved it could be massive, but their stock has fluctuated a whole lot just based on the ups and downs of this one product over the...
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    Investing General Discussion

    The stock offering immediately after the positive press release is a pretty common strategy in biopharma, especially for pre-revenue companies like Moderna. I think the main issue is that they chose not to share any actual data (which can be used to objectively judge their results), but made...
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    Divinity: Original Sin 2

    I just started playing this and am only on Act 2 but it's great. Really scratches the Baldur's Gate itch and makes me hopefully that they can deliver on BG3. I wish there was more distinction between classes, but it's also kind of fun to mix and match skill trees to build a unique character...
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    Survivor

    The whole fire tokens gimmick needs to be removed or rebalanced. So the first person voted out gets basically a massive advantage but spending a month hoarding fire tokens? Admittedly, Natalie was physically crushing it and that helped her a lot, but she basically bought her way back in to the...