Kithani
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Investing General Discussion
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Furry
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Moderna and Merck Present 5-Year Data for Intismeran Autogene in Combination With KEYTRUDA® (pembrolizumab) in Patients With High-Risk Stage III/IV Melanoma Following Complete Resection at the 2026 ASCO Annual Meeting - Merck.com
At a median 5-year (60.3 months) planned follow-up of the Phase 2b KEYNOTE-942/mRNA-4157-P201 study, intismeran autogene in combination with KEYTRUDA demonstrated a 49% reduction in the risk of recurrence or death and a 59% reduction in the risk of distant metastasis or death compared to...
www.merck.com
Data points with links to the clinical trials. Looks promising on a skim.
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Arden
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Haus
I am Big Balls!
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Hearing a summary of how this thing works essentially it is this :
- You get diagnosed with Melanoma
- They take a sample of the cancer from you
- Since it's based on your genetic they have to gene sequence it.
- Look at that compared to your regular genetics and look for markers that differentiate the cancer
- Build a custom mRNA vaccine based on those specific markers to target your specific cancer
- Deliver it, and couple it with a known immuno-booster to amp up it's behavior
- Effectively attacks the melanoma
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Sheriff Cad
scientia potentia est
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It's not too different than how CAR-T therapy is working now.
With CAR-T, they remove T-cells from the cancer patient, get them to divide in the lab and then use a viral vector to reprogram the DNA of the T-cells to attack your specific cancer. Then they put those reprogrammed T-cells back into you and your immune system goes wild attacking the cancer.
Sounds like two approaches to getting your immune system to attack the cancer.
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Sheriff Cad
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Everything is expensive at first and gets cheaper over time, like your mom.
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Arden
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Haus
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So once again I come for an opinion from those who are deeper on these stock strategy topics than I am..
I have been working with an actual professional financial planner and they brought up one tool they wanted to talk about that made my "something seems fucky here" sense go off.
A managed fund they run to essentially operate like an index fund with similar returns while also maximizing a tax loss farming strategy to bring down overall tax obligation for other moves I make which will generate large capital gains hits. Is this a real thing? It's being recommended by a large, well known, name in financial planning, but just seems like some slightly dodgy fuckery going on. I'm probably going to be moving a large amount of capital out of an over-concentrated position over the next 2-4 years, so the idea here was to play a strategy of generating and harvesting tax losses to offset as much of the gains as possible. But in my head that means losing a ton of money??
I have been working with an actual professional financial planner and they brought up one tool they wanted to talk about that made my "something seems fucky here" sense go off.
A managed fund they run to essentially operate like an index fund with similar returns while also maximizing a tax loss farming strategy to bring down overall tax obligation for other moves I make which will generate large capital gains hits. Is this a real thing? It's being recommended by a large, well known, name in financial planning, but just seems like some slightly dodgy fuckery going on. I'm probably going to be moving a large amount of capital out of an over-concentrated position over the next 2-4 years, so the idea here was to play a strategy of generating and harvesting tax losses to offset as much of the gains as possible. But in my head that means losing a ton of money??
Sheriff Cad
scientia potentia est
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Without seeing the numbers my knee-jerk reaction is it sounds like they get you on the management fee in their managed fund in order to get some perceived tax gains later - but the tax gains won't offset the management fee. But you'd have to run the numbers on that for your particular situation.
One of the reasons unmanaged index funds are so good is the like 0.01% management fee.
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