I used to think that the control setup was bad (for controller), but the more I played I realized its not the input combinations themselves, rather its using them to interact with the world / UI which is annoying at times. Like the forward momentum characters have that has you move into a space you didn't intend, the weird inventory management hoops you need to do. I was up around Varnia farming Ivory to upgrade various Cloaks, hunting Elephants and Rhino's. Trying to skin them was frustrating, since you had to find the exact spot for the skinning prompt to light up even though you're right next to it (this just happens with large animals, small ones haven't given me such issues).
Hell, I have no idea how to target lock, sometime it happens, sometimes it doesn't, not sure what causes it, lol. I'm still learning combat combo's too. I have an Abyss Gear (Volcanic) which I had solely for my Charged Shots, since it will nuke one target then send out these fireballs that can kill small enemies and send them flying. Very fun. Yet, yesterday while spamming my RT heavy attack I hit "Y" and the same effect happened, it was suprising and satisfying. So now if I see a clump of mobs, I run into them and pop off RT+Y... explosions happen. Fun.
Find an interactive map for CD, hide all the markers except for "Caves". Pick one and go exploring in that direction. Stop now and then to use "Blinding Flash" to check for nearby Puzzles or Teleports / Sealed Artifacts. It is a huge world.