Pretty sure in the second+ dungeon, you only get 1 curse removed, and your curse level remains unless you get an artifact that removes it. I've always gotten to pick a curse to remove, but my curse amount/lvl has always stayed, or I just have a bad memory about that. =)
Game has a really solid base, the combat / weapons / combos and the curse mechanic + reward rooms all work together really well. Just needs to be fleshed out with more mob / boss variety (I would prefer a pool of bosses you can fight at the various stages, rather than the same boss each time).