I tried this for a few hours over the weekend. As a total n00b to the series I think my biggest point of confusion is that I have no reference point or other clear indication as to whether I'm actually doing well or not. I've been playing as Naples and after restarting a handful of times I thought I was starting to grasp some of the essentials. Money starts flowing in, I'm able to fund new/expanded production, roads, and advancements, and I manage to balance all four Estates and keep them hovering around 50% or higher. Then after a while things inevitably start going to shit. Three out of four Estates spiral into the red one-by-one, then the plague rolls in, then the Ducats dry up and I'm drawing chain loans, then finally all four Estates hate me, the Papal states constantly work to usurp my throne, and everything seems out of control. Is that simply an inevitability of the time period and I just need to dig my way out of the shit pile, or am I doing 75 different things wrong? Maybe it's both?
In any case, as a history dork, the insane depth of the game is impressive.