I felt great until I was about 35, then things started accumulating to the point where I was losing sleep occasionally, then regularly, because of injuries.
The good news is that if you can devote an hour a day, 3-6 days a week, you can change a good bunch of that. One of the biggest revelations in my life was understanding that working out is just physical therapy for injuries you already have, and the ones you don't have yet.
My back and knees were pretty bad a year ago, but after building a home gym and devoting the time to it, my back only gives me problems when I'm doing fucked up shit for extended periods of time, and my knees are good more days than they're not. That's a pretty huge thing.
I don't give a shit about appearance though. Can't fight the gray hair and the crows feet. Might as well age gracefully. Occasionally we have guys come into work with huge hives or rashes on their forehead because they got a reaction from their new hair dye.
We laugh a lot.