If you're only gonna run with 1 graphics card, I'd say go matx on the mobo and get a silverstone tj-08e case. I have a 3570k, 8 gigs ram, 2 570s, 120 gig ssd, and 2 hdd in mine. All components stay cool. I use an h60 in push/pull. I have the CPU overclocked to 4.4 ghz and temps are fine.
If...