I have to admit, I almost always resign myself to a loss when we've got two lanes down and no more throne towers. It annoys me when the guys I play with insist on defending and then the 1 or 2 pubs that are with us get picked off while pushing back a lane and we lose in 10 minutes instead of 2 (had we not defended).
But I might've just been converted to their way of thinking.
I just had the most epic comeback game. We had an axe and dark seer who were doing some gay shit bot lane (we were dire) and got as many kills as they gave (they gave first blood because the other team sent 4 bot because the combo was so obvious, I guess?). Anyway, they started doing really bad when mid (Invoker) started coming to help radiant's bot lane. I was legion commander, jungling and coming out to gank every other minute or so.
Nobody spoke english on the team, or at least they didn't indicate that they wanted to communicate for the first ~40 minutes of the game. This made it really hard to coordinate as pings were often not indicative of urgency or when to attack so they quickly became ignored. What's worse is we had an omni who insisted on repelling me every time I Duel'd someone and it stopped the duel. I had 0 bonus damage from duels until ~40 minutes in the game.
Anyway, the other team was doing whatever the fuck they wanted. Axe would get picked off because they were warding the jungle and he was perma-oblivious, Dark seer would rush in to help his buddy and suddenly it's 3 v 5 at the base tower. That's how we lost the first two lanes.
Then our weaver caught them roshing after an unsuccessful push on our last lane and we wiped the team. This was the turning point. This was ~50 minutes in and weaver and I were 6 slotted (well, I was at least; not 100% sure about him). I finally had SOME duel damage, but less than 100. We managed to get the mid melee rax and backed up. I ended up dying but my team were all up by then and they defended without incident.
We were a little more emboldened now and started pushing mid up beyond the river. A couple of them over extended and we killed them after their buddies stopped pursuit. The rest, as they say, is history. We ended up winning with megas, and my epeen grew at least an inch.
tl;dr: Dota is a fickle mistress; sure she'll make you rage, but every now and then she'll make you feel unfuckingtouchable.
http://dotabuff.com/matches/439524364