This was covered elsewhere but there are something like 4 characters total who are "4th wall aware". Off the top of my head I know She-hulk is another, and supposedly Gwenpool. I can't remember the 4th. But yeah, I strongly suspect there will be a "kick you true believers in the feels" 4th wall moment in the next Deadpool flick.
Marvel Comics the Untold Story is a good read if you want some insight on the history of Marvel and Lee's place in it. Though, you probably won't have as shiny a picture in your mind of him after reading it.