Weight Loss Thread

Khane

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You are taking an unofficial version of the drug from a drug compounder, she is taking the official version from Eli Lilly. What you are doing COULD be dangerous because you don't quite know exactly what they are doing. That being said lots of people are doing what you are doing precisely because of the cost and I haven't really heard any horror stories.

It probably explains why you were getting sick on higher doses though, the dosages may not be quite right from this Pomegranate place.
 
ShakyJake

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Onoes said:
I'm paying less for my Tirzepatide though, I did a 6 month plan for $700 from a website called pomegranate health on the recommendation of a friend. I was supposed to do a month at 2, then a month at 4, then 6, then 3 months at 7.5. I had no issues at 2 or 4, but when I went to 6 I felt sick as shit for days. I genuinely thought I caught something. Same thing happened the next week when I did it again. I dropped to 5 and was a little nauseous for 24ish hours but otherwise felt fine. Since that seems to be working for me I'm just sticking with 5, which should make my vials last 7.5 months, so under $100 a month.

I know a girl taking 17.5 per week and she is spending $540 a month on it. I was telling her how crazy that is and she said when she was on Ozempic she was spending more than 1k a month. I'm such a cheapskate that is insane to me.
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I'm confused, what are these numbers you're speaking of? "2, 4, 7.5", etc
 
Furry

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Khane said:
I haven't really heard any horror stories.

It probably explains why you were getting sick on higher doses though, the dosages may not be quite right from this Pomegranate place.
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I wonder what the long term consequences of using ozempic type drugs will end up being. Seems like a pretty strong medication for people in a lot of situations, and from what I've seen it seems to work better for men than women. I've seen people quit and then in a few months the weight bounces right back on.

I mean good on people who use it as a wedge to experience losing weight if they have had long term trouble, I just hope they can develop the good habits that help them sustain it long term, because a life time subscription to medication like that just sets off alarm bells in my head. I'm very against taking medicine that isn't temporary.
 
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Khane

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Furry said:
I wonder what the long term consequences of using ozempic type drugs will end up being.
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Ozempic has been FDA approved since 2017 FWIW. I know it seems like a new drug because its newer part of the cultural zeitgeist but its been around and in use by diabetics for a while.
 
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Armadon

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I'm a big fan of splitting up your doses. I do 5mg of reta a week so I split the dose up to 1mg a day Sunday thru Thrursday. I've never had side affects or any type of trouble.
 
moonarchia

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Khane said:
Ozempic has been FDA approved since 2017 FWIW. I know it seems like a new drug because its newer part of the cultural zeitgeist but its been around and in use by diabetics for a while.
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It was approved for diabetics in 2017. It wasn't approved for weight loss until later. That was when demand went through the roof.
 
moonarchia

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Furry said:
I wonder what the long term consequences of using ozempic type drugs will end up being. Seems like a pretty strong medication for people in a lot of situations, and from what I've seen it seems to work better for men than women. I've seen people quit and then in a few months the weight bounces right back on.

I mean good on people who use it as a wedge to experience losing weight if they have had long term trouble, I just hope they can develop the good habits that help them sustain it long term, because a life time subscription to medication like that just sets off alarm bells in my head. I'm very against taking medicine that isn't temporary.
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They don't change their habits, which is why they blimp up immediately afterwards. If you aren't going to be on the medication for life, it's just a temporary bandaid. There is no escaping from the science. Eat less calories. Permanently. That is the only way to get to there and stay there.
 
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Cad

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ShakyJake said:
Mine is measured in milliliters. Started off at .15ML and moved to .20ML. Felt pretty awful at that level and never increased it. At month two they wanted you to go to .50 and I was like hell no.
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There's a dosage on your vial that tells you how many mg per mL, you dose volumetrically. Compounded tirzepatide typically comes in 17 mg/mL and 20 mg/mL.

So if you have 20mg/mL and you want 2mg, you would measure out .1mL. (for example). You'd have to look at your vial to determine how they compounded it.
 
Noodleface

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First GLP-1 approved by FDA was in 2005, so there are long-term studies. It wasn't until ozempic that people went crazy about the weight loss side.
 
mkopec

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There has been a lot of shit approved by FDA when years later it is found to be leading cause in killing people.

32% of FDA-approved drugs are later flagged for safety issues, ranging from new "black box" warnings to full market withdrawals. [1, 2, 3, 4]

These are some of the major ones...

  • Vioxx (Rofecoxib): Recalled in 2004 after five years on the market. It was prescribed to over 20 million people for arthritis but was found to significantly increase the risk of heart attack and stroke. [1, 2]
  • Bextra (Valdecoxib): Recalled in 2005 due to increased risks of heart attack, stroke, and life-threatening skin reactions like Stevens-Johnson syndrome. [1, 2]
  • Duract (Bromfenac): On the market for only one year (1997–1998). This painkiller was withdrawn after reports of severe liver damage and deaths, particularly in patients who took it for longer than the recommended 10 days. [1, 2, 3]
  • Posicor (Mibefradil): A blood pressure medication withdrawn in 1998 after one year. It was suspected in roughly 100 deaths due to fatal heart rhythm disruptions and dangerous interactions with other drugs. [1]
  • Raxar (Grepafloxacin): An antibiotic withdrawn in 1999 following reports of 13 patient deaths related to fatal heart rhythm disruptions. [1]
  • Raptiva (Efalizumab): A psoriasis drug withdrawn in 2009 after being linked to a rare, fatal brain infection called progressive multifocal leukoencephalopathy (PML). [1, 2, 3, 4]
So just because something is "FDA approved" really does not mean shit in reality.
 
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Khane

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mkopec said:
There has been a lot of shit approved by FDA when years later it is found to be leading cause in killing people.

32% of FDA-approved drugs are later flagged for safety issues, ranging from new "black box" warnings to full market withdrawals. [1, 2, 3, 4]

These are some of the major ones...

  • Vioxx (Rofecoxib): Recalled in 2004 after five years on the market. It was prescribed to over 20 million people for arthritis but was found to significantly increase the risk of heart attack and stroke. [1, 2]
  • Bextra (Valdecoxib): Recalled in 2005 due to increased risks of heart attack, stroke, and life-threatening skin reactions like Stevens-Johnson syndrome. [1, 2]
  • Duract (Bromfenac): On the market for only one year (1997–1998). This painkiller was withdrawn after reports of severe liver damage and deaths, particularly in patients who took it for longer than the recommended 10 days. [1, 2, 3]
  • Posicor (Mibefradil): A blood pressure medication withdrawn in 1998 after one year. It was suspected in roughly 100 deaths due to fatal heart rhythm disruptions and dangerous interactions with other drugs. [1]
  • Raxar (Grepafloxacin): An antibiotic withdrawn in 1999 following reports of 13 patient deaths related to fatal heart rhythm disruptions. [1]
  • Raptiva (Efalizumab): A psoriasis drug withdrawn in 2009 after being linked to a rare, fatal brain infection called progressive multifocal leukoencephalopathy (PML). [1, 2, 3, 4]
So just because something is "FDA approved" really does not mean shit in reality.
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This is true, but how many of those medications are being taken by as many people as these GLP-1s? These things are being taken by probably more people than any precription medication ever, so known side effects should get hammered out "somewhat" quickly.

Claude says this:
Ever used (lifetime): A 2025 RAND survey of a nationally representative sample found that about 11.8% of U.S. adults reported having used a GLP-1 agonist — roughly consistent with a 2023 KFF estimate. That translates to roughly 30 million Americans who have tried one of these drugs at some point. 30 million just in America and growing each year so we should know pretty quickly, like with the Vioxx in your example, which was recalled after 5 years (Ozempic is almost 10 years old)
 
mkopec

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Rough estimate at a search said 30 million but this is up from 8 million in 2024. So about the same as Vioxx. I mean Im not saying that this shit is not safe. Im just saying not to trust "FDA approved" either when literally 30% of their approvals end up killing people at worse. Its a fucking magic weight loss pill so yeah, people will get on board, especially now that it s in pill form and you dont have to inject the shit. People spend billions per year on weight loss shit. So yeah. Remember that olestra shit? LOL? Hey maybe ill shit myself to death but at least I get to have my chips.
 
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Noodleface

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My point was really that there were long-term studies, but I get what you mean. I just think there's a general misconception that Ozempic was the first iteration of GLP-1 but people have been on it for awhile now.
 
moonarchia

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mkopec said:
Rough estimate at a search said 30 million but this is up from 8 million in 2024. So about the same as Vioxx. I mean Im not saying that this shit is not safe. Im just saying not to trust "FDA approved" either when literally 30% of their approvals end up killing people at worse. Its a fucking magic weight loss pill so yeah, people will get on board, especially now that it s in pill form and you dont have to inject the shit. People spend billions per year on weight loss shit. So yeah. Remember that olestra shit? LOL? Hey maybe ill shit myself to death but at least I get to have my chips.
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I would love some olestra from time to time if they still made those chips. A fully purged small and large intestine would be nice.
 
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