Weight Loss Thread

Noodleface · Sunday at 4:55 PM

There's straight GLP-1 like ozempic and then tirzepatide (GLP-1 and GIP) like Mounjaro. I've taken both and after initial side effects (really bad nausea) Ozempic seemed to have less overall side effects for me. That said, they're all really manageable. The worst I get now is a lot of heart burn.

The shit does work though, but I think there are people abusing them. I went on it for the betes but hang out on the mounjaro sub and you'll see tons of people taking it that really shouldn't.

My guess is the pills will have less side effects because you're taking it daily rather than a "big" shot once per week.

Speaking of it. Only started tracking in Feb but I started at 235 in late October.

Control · Sunday at 10:11 PM

Sludig said:
So know someone that is pretty insistant they want to try one of these various new weight loss wonder drugs. I know the shots only known effective and a lot of slop pill forms. Is there one of the 3? that is likely less bad effects than the others? Woman of course. Just wish they would hold out until another blimp at the office would try it and see if her heart explodes first.

Tell her to go with injectable tirzepatide/zepbound imo (also not a doctor, don't listen to me!). The pills are newer and somewhat less effective I think, don't know too much about them, but the shots are a pretty known quantity (at least as know any any modern-era pharma is).

zombiewizardhawk · Sunday at 10:57 PM

Kithani said:
I’m not super obsessed and I’ve never heard of this brand but a quick google seems to show they claim to have 28g protein in a 150 calorie chocolate bar?

That like the protein content of a chicken breast lmao

For a junk food bar usually I aim for 10:1 calories per gram of protein that’s almost double it

It's also about the protein content of 1 scoop of any whey protein powder, which I always assumed was what companies were doing for all that stuff.

ShakyJake · 2026-04-27T08:52:46-0400

Sludig said:
So know someone that is pretty insistant they want to try one of these various new weight loss wonder drugs. I know the shots only known effective and a lot of slop pill forms. Is there one of the 3? that is likely less bad effects than the others? Woman of course. Just wish they would hold out until another blimp at the office would try it and see if her heart explodes first.

I just started this about 3 weeks ago:

https://www.emergeweight.com/

Injectable, but totally painless, and stupid easy to get the prescription. I'm not a lard ass at all, just beginning to get the "middle age spread" despite a regular workout regimen. Weight has been slowly creeping up over the years and wanted to knock it back down a few pounds.

Noodleface · 2026-04-27T09:43:55-0400

ShakyJake said:
I just started this about 3 weeks ago:

https://www.emergeweight.com/

Injectable, but totally painless, and stupid easy to get the prescription. I'm not a lard ass at all, just beginning to get the "middle age spread" despite a regular workout regimen. Weight has been slowly creeping up over the years and wanted to knock it back down a few pounds.

I mean this in no offense but these medicines aren't really designed for knocking down a few pounds.

moonarchia · 2026-04-27T10:45:55-0400

Noodleface said:
I mean this in no offense but these medicines aren't really designed for knocking down a few pounds.

The only reason Ozempic works is due to it suppressing hunger. There are no magic bullets to weight loss. There is only diet and exercise.

ShakyJake snake oils everywhere. Always been that way. Portion control is the only thing that will help you lose weight long term, same as everyone. Count your calories, and eat slightly less than for the weight you are aiming for. Then eat for that weight when you get there to maintain. If you aren't the one making meals, you are going to have to eat less. My dad fails at losing weight due to this. My mom makes meals for 10 for the 2 of them and gets irritated if you refuse to gorge yourself.

Khane · 2026-04-27T10:51:20-0400

These GLP-1's literally are magic bullets for weight loss, among a myriad of other benefits that are still being discovered. And they don't just suppress hunger.

Pharma companies are obviously greed ridden corporate machines but sometimes they actually create some pretty incredible things for our health. GLP-1's are some of the closest drugs to "sci-fi" level super serums that I've seen.

ShakyJake · 2026-04-27T10:54:02-0400

Khane said:
These GLP-1's literally are magic bullets for weight loss, among a myriad of other benefits that are still being discovered. And they don't just suppress hunger.

Oh they definitely suppress hunger. I can totally see someone barely eating anything and getting by. Very dangerous.

Noodleface · 2026-04-27T11:03:25-0400

Yeah I mean I've been on it 6 months and it is definitely a magic bullet. It does two main things:
1. Causes satiety much quicker when you eat
2. Slows gastric emptying so you stay full longer

There's also lots of research being done with its benefits as an anti-inflammatory.

It should be standard care no questions asked for morbidly obese people.

Khane · 2026-04-27T11:03:57-0400

ShakyJake said:
Oh they definitely suppress hunger. I can totally see someone barely eating anything and getting by. Very dangerous.

They also slow gastric emptying (which is what ends up causing all the digestive issues for most people). They're also studying them for various addictions like alcohol and nicotine because they apparently suppress those cravings as well.

Weight loss discussions almost always turn into schadenfraude and finger wagging but these drugs are... pretty wild.

BrutulTM · 2026-04-27T11:19:51-0400

They seem pretty impressive for obese people but I do think there are some issues with people with body dysmorphia getting their hands on them and Karen Carpentering themselves. I've heard of people having serious health problems because they just stop eating.

moonarchia · 2026-04-27T11:44:40-0400

BrutulTM said:
They seem pretty impressive for obese people but I do think there are some issues with people with body dysmorphia getting their hands on them and Karen Carpentering themselves. I've heard of people having serious health problems because they just stop eating.

Obese people become obese by having poor impulse control. A drug that imposes control is a life changer for them. The problem is that once they go off the drug they are going to go right back to where they were. A proper diet and exercise regimen builds that control personally, and lasts as long as you maintain it.

I have been on Ozempic for my beetus since before it became famous for weight loss. It is a useful drug for sure, but for weight loss it is a bandaid at best.

Cad · 2026-04-27T11:58:05-0400

Tons of gym guys are cruising on test/reta, it seems common. Guys in the gym have gotten leaner walking around in the last few years, I kind of assume a lot of it is GLP's. Good idea or not, a ton of people are using them that way, just for getting lean/weight loss.

moonarchia is 100% right though, if you don't build good habits it's not going to help you much when you go off it. The only thing I would say is it may teach them that they don't actually "need" all that food and maybe they can put the fork down.

Khane · 2026-04-27T12:02:48-0400

Gotta build good habits and resolve yourself to living healthy no matter what. With or without GLPs

Noodleface · 2026-04-27T12:04:38-0400

Khane said:
They also slow gastric emptying (which is what ends up causing all the digestive issues for most people). They're also studying them for various addictions like alcohol and nicotine because they apparently suppress those cravings as well.

Weight loss discussions almost always turn into schadenfraude and finger wagging but these drugs are... pretty wild.

Yeah absolutely.

Coincidentally I'd say for a long time I was addicted to fast food. I haven't had any since maybe December. I just don't feel the call anymore.

My worry with someone like

ShakyJake saying he went on to lose a few pounds is that's absolutely not what it's for. To lose a few pounds just eat better.

Control · 2026-04-27T14:29:39-0400

moonarchia said:
for weight loss it is a bandaid at best.

but it's a bandaid that lets people drop 100lbs that they wouldn't have otherwise dropped so...
yeah, fat people should have better habits, but if you're 50, 100+lbs overweight, and haven't managed to sort out the "better habits" part yet, how likely is that to happen? Maybe people have to be on it forever, but they were probably going to be on statins, blood pressure meds, and whatever else to deal with the fattness otherwise, right?
I mean it probably ends up giving us all turbo-stomach cancer in 10 years, but at our ages, being significantly overweight is a ticking timebomb of it's own. So reasonable calculated risk imo. For people who are just slightly overweight, I'd think a lot harder about the possibility of unforseen side effects showing up in a decade.

Cad · 2026-04-27T14:35:08-0400

Control said:
but it's a bandaid that lets people drop 100lbs that they wouldn't have otherwise dropped so...
yeah, fat people should have better habits, but if you're 50, 100+lbs overweight, and haven't managed to sort out the "better habits" part yet, how likely is that to happen? Maybe people have to be on it forever, but they were probably going to be on statins, blood pressure meds, and whatever else to deal with the fattness otherwise, right?
I mean it probably ends up giving us all turbo-stomach cancer in 10 years, but at our ages, being significantly overweight is a ticking timebomb of it's own. So reasonable calculated risk imo. For people who are just slightly overweight, I'd think a lot harder about the possibility of unforseen side effects showing up in a decade.

Cholesterol and blood pressure meds are a band-aid as well, if you go off them you go back up.

Nobody says not to take those. People are judgy about weight-loss stuff because they are petty fat fucks, or they're skinny and think the others didn't "earn" it.

Anything that gets us less fat people I have to look at walking around is great by me.

moonarchia · 2026-04-27T14:51:41-0400

Control said:
but it's a bandaid that lets people drop 100lbs that they wouldn't have otherwise dropped so...
yeah, fat people should have better habits, but if you're 50, 100+lbs overweight, and haven't managed to sort out the "better habits" part yet, how likely is that to happen? Maybe people have to be on it forever, but they were probably going to be on statins, blood pressure meds, and whatever else to deal with the fattness otherwise, right?
I mean it probably ends up giving us all turbo-stomach cancer in 10 years, but at our ages, being significantly overweight is a ticking timebomb of it's own. So reasonable calculated risk imo. For people who are just slightly overweight, I'd think a lot harder about the possibility of unforseen side effects showing up in a decade.

Fair enough. But most people are not going to be able to afford Ozempic indefinitely at current prices. $1000 a month meds that aren't needed are a luxury item.

Control · 2026-04-27T14:54:43-0400

moonarchia said:
$1000 a month

doesn't seem too hard to get insurance to cover it, depends on the company though of course. also, there are other options.
edit: also, when you deduct the cost of the food you're not buying, even the expensive options start to sound reasonable

Cad · 2026-04-27T15:16:24-0400

Costs peanuts to actually make, it only costs that in the US.

USA:
$675 per month for Ozempic, Wegovy, and Rybelsus starting January 2027 (35–50% reductions), but self-pay/direct programs remain unaffected by this specific change.

UK: ~£120/month

Europe (e.g., France, Germany, Netherlands, Sweden): Ozempic list prices historically $80–$170/month

Production costs are estimated at just $3–$16 per month (injectable vs. oral), highlighting the markup disparity.

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Weight Loss Thread

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