Trying to TLDR this from its original narrative form but it's still a lot:
I wrote a really long post explaining my medical history, (I'm a 34-year T1D) my relationship with weight, exercise, and fitness (I've lifted since I was 13, played football in hs/college), I've been fit and fat, gained and lost weight, etc. I have weird biochemistry (as one might expect from a T1D), tried Ozempic (it made me super sick, like vomiting sick, even in the titrate stage. I also had a NAION event (Non-Arteritic Anterior Ischemic Optic Neuropathy) in my left eye while taking it, so I wasn't keen on going back on another GLP-1. I still tried to stay fit even though I hurt my back in the aftermath of Hurricane Beryl (not a long story but not germane), and after that my weight, already a yearly loss/gain problem compounded by insulin, shot up.
I am trying to fend off multiple diabetic complications (chronic kidney disease, glaucoma, etc), have another autoimmune disorder that jumped during COVID (Rheumatoid Arthritis, which was horrible at first but now not as bad; wondering if that wasn't a COVID vaccine injury). So everyone is on board with me trying to lose weight.
My A1C has been good: 5.9-6.1 for the past 4 years. My endo and nephrologist continue to sound the drum, and I know I have to unlock a way to lose weight. I don't want to have bariatric surgery. Just dieting down on my own via 1500ish calories a day this time without a workout routine as before (2x a day workouts, 1500x a day pushups in the morning, swim/cardio weights 5x a week at night) produced zero weight loss.
So with all that backstory, I wanted to relay my recent experience with Mounjaro: Even on the starting 2.5mm dose, I have lost 22lbs in 12 days. I did this primarily by moving to an OMAD diet of 800-1200 calories and dramatically reducing my insulin dosage; I now take less insulin per day total, long-term and fast-acting, than I used to take to cover a single meal fast-acting. I am very strongly affected by the GLP-1s (in this case GLP-1/GIP), as my experience with Ozempic demonstrated. I still am doing some exercise, I am loathe to call them workouts, 200 pushups 3x a week and 5min walks on a walking pad 3x week, I could do nothing but drink water and type to the same effect, I think: Without the insulin level that high, my body isn't going to hold this much fat and as such is burning it off/letting it go, like a bodybuilder going off a cycle.