I actually find min/max running very boring and annoying so I don't really do it. I prefer to just go at my own pace and enjoy the game than stress out about losing 30 seconds like I do when I'm speed running.
Also! An update on the Rend build I was talking about above. Two changes:
Switch the WotB rune from Insanity to the one where you gain time for fury gained. Pretty much as long as there are mobiles around your WotB will stay active.
Switch out Revenge (forget what I had in the build I outlined -- maybe it was Quake) for HotA w/ Smash. Basically since you're taking so much damage you'll always be sitting at full fury. So for boss packs you basically Rend, HotA spam, Rend, HotA spam. If you are running low on Fury just cleave a few times to get to full.
Its pretty faceroll. My gear isn't great but it is bringing MP5 to it's knees.