A motorcycle might work, much like a horse in Skyrim. Ther vertibirds might be pilotable from what we see in the 22 minute trailer. That would work well.
Cars wouldn't work.
In Mad Max, the world is way huge, but way empty to leave plenty of room for car to car combat, one of the big draws. Plus the Mad Max world is mostly desert, like wide open desert, because its set in Australia which is already mostly flat and mostly desert, even before the bombs drop.
Even with a larger map this go round, there will be too many buildings, too much stuff in the way.
A vehicle based Fallout would require being set in the West like the original Fallouts, and Bethesda isn't going to do that any time soon. They're committed to the East Coast as a way of breaking free from the storyline for NCR and all that in the old games.
But since Skyrim has horses, it wouldn't surprise me if motorcycles were in it (though I think they'd have made a big promotional push about them if they were) and it wouldn't surprise me if a motorcycle gets modded in shortly after launch.