For the pure base weapons, I find daggers and staff the easiest to build up. For daggers, backstab and dash upbrades. Staff works best with the omega attack with the line which does very good damage and is fairly easy to build. The cloak weapon I just can't get the first aspect to even get past the first few guardians. Base damage is just so low and the attack (rapid hits) just feels like a 1/3rd damage dagger. I know one of the skull aspects can make some very high damage builds using the special. It might be the normal one, I've never gotten it though. Some of the builds kind of need you to know what boons to get and build around that using the different trinkets.
For upgrades that I've tried. Wands, I just did my first run with those and easily killed Chronos. Parry daggers are very good if you get the timing down.