I started my game over (maybe 3 hours in )because I used the reduce wanted level cheat, and lost the ability to manually save, which I knew was going to happen, but word of advice that cheat doesn't clear bounties etc. The tutorial is brutal the second time around.
I got used to the controls, but trying to loot houses etc is tiresome, you move so slow, and sometimes trying to loot a specific item takes too long(thinking of the first shady business you encounter) Also i wish the inventory system was managed a little bit easier, once I but gun accessories like a gun bandoleer etc, it was there for good.
I find being good makes life a lot easier but even then you're treading on egg shells because the whole witness / wanted system is very awkward.