Funny thing is the show's got fuck all to do with the actual LoL game other than having some of the characters in it. Nothing about the actual league, nothing about the summoner's rift, nothing about nexuses or minions or towers. That's probably for the best too. There's no way to contort MOBA gameplay into a narrative and not have it suck ass. It would've been worse than when they made that movie about Battleship the board game.
It's like how Alan Moore said that comics can do things that novels and films can't, and novels and films can do things that comics can't. I feel that's one of the things Riot got right in adapting their own product into a new medium that other videogame adaptations got wrong: they understood implicitly that games as a medium convey an entirely different experience than film. So, they just made a whole other product that told their game's story in a way that the new medium can do best.