For me I guess the 2 key things would be cutting the tail of Priscilla, WITHOUT KILLING HER, fucking bitch died on me like twice and once it autosaved so it fucked the whole save, it was my dagger playthrough too iirc. Second one was finding out the room for the 4kings actually had invisible walls, which made it impossible to kill them using a bow only for my bow playthrough(damage too low to keep killing them before next one spawned, and kiting impossible when you suddenly roll into an invisible wall so you get hit). Mostly small details, overall the game was pretty hard the first time around, but after that once you had died 30times to a boss on your first playthrough, the next time was like "eh whatever, oversized trash mob".