As noted by Adam Jahns of the Chicago Sun-Times, since 2000 there have been 14 instances of a team trading up to draft a quarterback in the first round, with most of them going horribly wrong.
While the Giants (Eli Manning, 2004) and Ravens (Joe Flacco, 2008) have won Super Bowls with those quarterbacks, most of the rest were busts.
A few such as Michael Vick (Falcons, 2001), Jay Cutler (Broncos, 2006) and Mark Sanchez (Jets, 2009) have had some degrees of success, but the rest of the list should give you chills: Kyle Boller (Ravens, 2003), J.P. Losman (Bills, 2004), Jason Campbell (Washington, 2005), Brady Quinn (Browns, 2007), Josh Freeman (Buccaneers, 2009), Tim Tebow (Broncos, 2010), Blaine Gabbert (Jaguars, 2011), Robert Griffin III (Washington, 2012) and Johnny Manziel (Browns, 2014).