So here's my experience from last night.
First city was going pretty OK until Godzilla stomped on my large firehouse, community college w/addons, and a crime wave hit. I ran out of money and was trying to sort it out when the game told me there was an issue (forget the wording, like the server and my game were in disagreement about something). Told me to leave and come back to fix the problem, since then I haven't been able to load the Rerolled region.
The second city was going well, got to 180k pop before I ran out of water to pump. The other players in the region weren't producing enough for me and I don't think you can buy it on the global market. So city went to shit and I let it go. Not sure what you're suppose to do if you're not using other cities to feed your main with water and you run out after four hours.
Also I must be doing something wrong with Gambling. My first building is always successful and does great. The second one is never profitable though. Even when I build a $250k "high tourist" culture building and set off an event from the Sydney Opera House it didn't seem to help at all.
I'll head off to work, probably sleep when I get home and play more tonight and tomorrow.