uBlock Origin, uBlock Origin Extra, and if you want to get even more granular control you can try uMatrix as well. The last one can take a while to get working on some sites as you need to go through and selectively unblock other domains (sorta like noScript) until it works well enough for you.
Another thing Twitch might be doing is emulating Youtube/Facebook and hosting ads directly from through their domain so blocking traditional ad hosts won't work as well.