100% honest, I lost a friend because of that.
At some point between ME2 and MEA, an officer from my old WoW guild that I kept in touch with post-WoW got involved in the SJ stuff. She and I were discussing the Andromeda trainwreck and I lost my shit at the Asari thing. I felt was out of place and didn't belong, especially with the established lore of the game universe. She took it as me attacking the whole gender identity thing in general, lost her mind at me, and we havent spoken since.
Personally I dont care what another person decides to do, dress as, call themselves, or whatever. You do you, just leave me alone, but dont change shit in my games to suit your agenda when the lore has been well established prior.