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Need some feedback on two orders I placed. I'm trying to decide which to keep. The first build is arriving this weekend and the second one will ship sometime in April. I currently have 2x 60Hz 1080p monitors but will probably upgrade to 1440, maybe 120/144Hz. Don't currently care about 4k...

Try minimizing big picture mode and starting the game from the desktop.

I had been holding VIR for about 9 months and just sold yesterday... Woops.

Well, that was an easy call for a 25% gain. MRNA was $77 when I posted this and it's around $100 today after they posted their efficacy. Might bump a little more or more likely will settle lower by the end of the week. All their preclinical data was really similar to Pfizer and they use using a...

It blows my mind that the opinion of someone like Andrew Left holds any weight, let alone enough to crash stocks the way he does over and over. Some of Citron's "research" papers are hilarious at how inaccurate and poorly-written they are, yet somehow they create a self-fulfilling prophecy that...

I enjoyed it, but I would have enjoyed it more if we didn't have the first season as a reference point for what the series is capable of. As a lot of you have mentioned, the plot here is much more of a slow burn, and there are no real dramatic twists. I remember how shocking it was to find out...

Moderna will likely be reporting efficacy data soon for its COVID vaccine. If you feel like gambling, this could really swing things up or down in the coming days (weeks?) depending on their efficacy numbers. All their data so far has looked great, but with such an early readout from a small...

To be fair, that's just placing an order to call dibs once doses are available. I guess it's nice that the money came from OWS, but some US agency would have ended up paying to reserve doses regardless. I'm not aware of Pfizer receiving any actual OWS support, and they are even using their own...

For anyone wondering if the Pfizer news is really that great: yes, in terms of vaccine effectiveness. 90% efficacy is great. If none of the vaccinated patients advance to severe disease then that's even better news, obviously. There's no bad news in this press release, but the safety profile...

I think it's just random. Our second kid cried all the time and our first hardly ever cried.

I am shocked that it looks like it will get approval - I guess the desperation for any treatment option justified a bit of a fishing expedition for any efficacy signal. For many years, A-beta antibodies have been used with varying degrees of success to reduce some symptoms, but the amyloid...

Decided to check this show out and powered through over the last couple weeks. I managed to avoid spoilers and I think for this show in particular it made things a lot more enjoyable. Towards the end - I guess for most of the third season - I did end up reading the wiki summary after finishing...

When I was interviewing for a job at Mayo in Rochester, I was told that it is quite common for middle eastern royalty to fly their family and friends straight in and pay in cash, even for minor ailments. Apparently there are also exceptionally high rates of rare inherited disorders because there...

Impressed by those of you willing to dive back in to the pool of homework and exams. Finally being finished with coursework for good was one of the best / most liberating feelings in my life. I really enjoyed grad school in particular due to the focused nature of many courses, but I never...

Keep in mind that study completion dates can be very misleading. A typical Phase 3 vaccine study will takes years. But then again, a typical Phase 1 study also takes a year or two, and we are seeing multiple companies skipping straight from Phase 1 to Phase 3 within months now. All the Phase 1...

Moderna is close to $100 per share now. $35B market cap and they haven't yet dosed a patient for phase 3. Very tempted to sell before the pullback, but I got burned doing that with NVAX so I'm just going to be patient and wait for approvals. If you are doing short term trading, all the vaccine...

Haha, well I can only assume the "double defense" refers to the hype/rumor that the Oxford + Astrazeneca vaccine is generating antibody and killer T cell responses, which would be very encouraging. As for the decades of protection... Uhh, maybe? I guess we'll find out in a couple decades? I...

Happy to help. 99% of this thread goes over my head, but I live and breathe the scientific side of biotech / pharma so hopefully it adds an interesting perspective.

Let me clear up some misinformation before this spreads anymore: Moderna, and all other frontrunners have completed animal challenge studies. A pre-print of their results in mice has been available for over a month, and I can guarantee you that they have completed NHP (monkey) challenge(s) as...

Definitely safer to stick with big pharma, and much bigger risk/reward with the small players. I invest for fun so I am most interested in trying to pick a winner based on "up-and-coming" technology. But I'm also prepared to see it all disappear with no warning.

BNTX up 18% so far. Although, all the big COVID vaccine stocks are all up 10% or so right now. It's almost a guarantee that there will be some more funding announcements soon for some of the frontrunners in the vaccine race. There's a whole lot of Warp Speed, DoD, CEPI, Gates, GAVI, etc...

You're in California right? Take the 6 weeks of paid family leave to bond. For my kids, I took the 6 weeks starting when they were about 3 months old. I got to be there for their first laughs, their attempts to crawl and roll over, and I spent a lot of time learning their habits and figuring out...

If you are following vaccine stocks, I would own BioNTech (BNTX) since they developed the vaccines and licensed to Pfizer. Obviously Pfizer can benefit from all this but I think BNTX is the one that can really explode. I'd also expect MRNA to report their complete phase 1 data soon (possibly...

This drop is hitting every company though. Probably the biggest drop in this industry since the pandemic hit. I think a lot of portfolios are unloading to take profits in case the pandemic dies down before Ph1 readouts start to trickle in and Ph2-3 studies kick off. I still think buying the...

Covid stocks getting annihilated across the board today.

They have a lot riding on their Alzheimer's drug, so their value this year might be tied to whether or not the BLA gets accepted by the FDA this fall/winter. If approved it could be massive, but their stock has fluctuated a whole lot just based on the ups and downs of this one product over the...

The stock offering immediately after the positive press release is a pretty common strategy in biopharma, especially for pre-revenue companies like Moderna. I think the main issue is that they chose not to share any actual data (which can be used to objectively judge their results), but made...

I just started playing this and am only on Act 2 but it's great. Really scratches the Baldur's Gate itch and makes me hopefully that they can deliver on BG3. I wish there was more distinction between classes, but it's also kind of fun to mix and match skill trees to build a unique character...

The whole fire tokens gimmick needs to be removed or rebalanced. So the first person voted out gets basically a massive advantage but spending a month hoarding fire tokens? Admittedly, Natalie was physically crushing it and that helped her a lot, but she basically bought her way back in to the...

Our first daughter was almost completely potty trained by the time she turned 2. We put her on the toilet whenever it seemed like she needed to go, or whenever it had been a while since she'd gone. Then rewarded and praised her for success. Was honestly pretty easy and not that much "work."...

Gilead announced that remdesivir hit it's primary endpoint in an NIH trial. This is in contrast to their failed trial in China. Likely the main difference is that the drug is given earlier and to less severe cases than they tried in China. The primary endpoint is time to recovery at day 29...

This was an American (FDA-approved) study from an American company that was initiated in February, when China was the only place to go to get hundreds of patients enrolled. I would trust this data.

Remdesivir clinical trial data was leaked by accident. I am no fan of Adam Feuerstein, but this looks legit. Was quickly taken down from the WHO site but here's a screenshot: Appears to have no effect, but enrollment was terminated early so this analysis won't have the statistical power it...

The answer depends on long term safety data for the vaccine(s), but the risk of actually dying from <insert vaccine here> is basically guaranteed to be lower than the disease itself. Even as a huge advocate of vaccines myself, it's fair to say that without years of follow up, there is some risk...

Essentially no chance a vaccine is available until next year. Even the end of the year would be unprecedented

I thought this season was great, definitely better than season 2. It felt at first like they were forcing Ben into the storyline at first but he did an amazing job and i thought it was fascinating to watch Wendy break down as she realized her only way out was to have him killed. My main...

Forgot about this post, but I have a positive update. I stuck it out and ended up getting the promotion a couple months later (~$25k raise) and another $10k pay bump in January for being a "key contributor" to the company. I didn't have to threaten to leave or go get another offer either so I...

I have to keep coming in to the office because I am a manager at an essential business in San Diego, and the commute has been amazing these past 2-3 weeks. It reminds me just how bad traffic has gotten in the last 10-15 years when I am celebrating a drive time less than 1 hour.

Maybe I was lucky to notice these things, but I realized there were at least two timelines approximately 30-40 years apart in the first episode. Queen Calanthe tells Ciri how she won her first battle when she was as young as her. Then the very next scene someone was telling Geralt that the young...

Question about the warrior mage whose only power was resummoning his sword: after he wakes up from getting knocked unconscious, he sees one of his fellow mages propped up against a wall asking for help. He grabs a mace and bashes the guy's head and just keeps beating on him for a while. At first...